Tacrolimus (FK 506)-dependent tolerance after liver and heart xenotransplantation: inhibition of humoral response and acceptance of donor organs.

Hamster-to-rat liver xenografts protect extrahepatic organs from rejection.

THE liver allograft is relatively resistant to the hyperacute rejection caused by preformed antibodies, I and in some species and strain combinations it is accepted without immunosuppression. 2•3 We have shown a similar resistance of the liver to humoral rejection after hamster to rat xenotransplantation. 4•5 Moreover. it has been shown that the liver allograft can induce tolerance to other org...

Differential survival of hamster-to-rat liver and cardiac xenografts under FK 506 immunosuppression.

THE ~aj~r bame~ in clinical transplantation has been the hmltatlon ot donor organs. I Xenotransplantation has been considered an alternative source of organs, however strong immunolOgiC barriers are thought to make this option impractical. The immunosuppressant FK 506 has been shown to be several hundred times more potent than cyclosporine (CyA)2.) and it is capable of suppressing antibody prod...

Intra-CA1 administration of FK-506 (tacrolimus) in rat impairs learning and memory in an inhibitory avoidance paradigm

Objective(s): Calcineurin (CN) is a main phosphatase and a critical regulator of cellular pathways for learning, memory, and plasticity. The FK-506 (tacrolimus),a phosphatase inhibitor, is a fungal-derived agent and a common immune suppressant extensively used for tissue transplantation. To further clarify the role of CN in different stages oflearning and memory the main aim of this study was t...

FK 506: an effective immunosuppressant for islet xenotransplantation.

R EPLACING the damaged insulin-producing tissue by transplantation of pancreatic islets is considered the most physiological approach to diabetes treatment and has the potential to prevent the development of chronic complications. Due to the large number of potential diabetic recipients. it would be impossible to obtain sufficient supply of donor organs to fulfill the demands. One solution to r...

Effect of FK 506 and antiproliferative agents for heart and liver xenotransplantation from hamster to rat.